Human Sera
Cayman Chemical DavuntIdeacetate 50mg
A neuroprotective ADNP-derived peptide; promotes tubulin assembly in a cell-free assay at 1 fM; protects against cytotoxicity induced by tetrodotoxin, a peptide derived from Aβ, or zinc in isolated neonatal cerebral cortical cells at 1 fM; intravitreal administration inhibits increases in cleaved caspase-3 and decreases in Bcl-2 in retina isolated from streptozotocin-induced diabetic rats; improves survival in a SOD1G93A transgenic mouse model of ALS at 10 UG/animal; prevents decreases in brain ChAT activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration
Cayman Chemical EmpaglIflozIn 50mg
An SGLT2 inhibitor (IC50 = 3.1 nM for the human transporter); reduces non-fasting blood glucose levels, as well as aortic superoxide levels and cardiac interstitial fibrosis, in db/db mice when administered in the diet at 0.03%; decreases the severity of glomerulosclerosis, as well as reduces the escape latency in the Morris water maze, in the same model
Cayman Chemical ArecolInhydrobromIde 100mg
A natural alkaloid in the betel nut; an agonist of the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5; causes smooth muscle contraction; has been shown to improve learning and memory and may prove to be useful in treating dementia
Cayman Chemical 1PalmItoyl2Oleoyl3ArachI 50mg
A triacylglycerol; has been found in lipid extracts from whole rat retina
Cayman Chemical CeramIdenon-hydroxybovIn 50mg
A mixture of non-hydroxy fatty acid-containing ceramides
Cayman Chemical DexmedetomIdIn 50mg
An α2-AR agonist; selectively binds to α2-ARs over α1-ARs (Kis = 0.015 and 5 nM, respectively); prevents increases in CTnI, as well as reduces myocardial apoptosis, pyroptosis, and ferroptosis in a mouse model of CLP-induced sepsis at 50 UG/kg; induces sedation and decreases mechanical nociception in cats at 40 UG/kg
Cayman Chemical NIcergolIn 100mg
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 UG/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Cayman Chemical 17phenl trInor ProstglndI 50mg
An F-series prostaglandin and an FP receptor agonist; induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM); ocular administration reduces IOP in normotensive dogs and ocular hypertensive monkeys at 0.03% w/v
Cayman Chemical FentIconazolenItrate 100mg
An antimicrobial imidazole; active against clinical isolates of Candida species (MICs = 0.12-32 μg/ml); active against clinical isolates of bacteria associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria associated with skin infections (MICs = ≤0.03->16 μg/ml); inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically)
Cayman Chemical Sulpho Nonate 100mg
Sulpho NONOate produces nitrous oxide but no NO at physiological pH. Therefore, this compound may be used as a negative control in experiments using other NO donors of the NONOate class.{875,5437}
Cayman Chemical GlutamInase-IN-3 100mg
An inhibitor of GAC (IC50 = 0.24 µM); inhibits the proliferation of PC3 and LNCaP prostate cancer cells (IC50s = 6.14 and 2.13 µM, respectively) and non-cancerous CCD-1072Sk fibroblasts (IC50 = 15.39 µM)
Cayman Chemical SIN-1chlorIde 100mg
Active metabolite of molsidomine that acts as a potent vasorelaxant and inhibitor of platelet aggregation; produces both NO and superoxide to generate peroxynitrite under physiological conditions
Cayman Chemical 4MethylpentnoIc AcIdd12 100mg
An internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS